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Modeling of the structure of StAR based on the crystallographic structure of the closely related protein, MLN64, suggested that StAR might act in the mitochondrial intramembranous space (IMS) [58], . However, StAR is active when immobilized on the outer mitochondrial membrane (OMM), and inactive when localized to the IMS [122] , proving that its action is determined by its subcellular localization, and not by its cleavage to the 30-kDa form ( Fig. StAR acts on the OMM. The upper panel shows the experimental approach used by Bose et al.

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